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Antiviral effect of polyphenol rich plant extracts on herpes simplex virus type 1

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2018-05-18 来源:九五至尊网址_九五至尊娱乐网址_九五至尊娱乐场网
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  作者:Sayed A. El-Toumya, Josline Y. Salib a,, Walaa A. El-Kashak b, Christel Marty c, Gilles Bedouxc, Nathalie Bourgougnon c

  关键词:Egyptian plants; Anti-HSV-1; Polyphenols; Vero cell

  内容:Evaluation of the anti-herpetic activity of 25 Egyptian plants extracts was investigated in vitro in this study. The antiviral activity against Herpes SimplexVirus type 1 (HSV-1)was done onVero cell lines by cell viability. Only two plants extracts; namely Euphorbia coopire (Euphorbiaceae) and Morus alba (Moraceae) showed potent anti-herpetic activity and six other extracts showed moderate inhibition. In contrast, a bioassay monitored phytochemical exploration of these two plants led to the isolation of pure flavonoid compounds. The antiviral activity of the isolated compoundswas also examined, among which seven pure compounds namely; 7-galloyl catechin, gallic acid, kaempferol 3-O- -(6 -O-galloyl)-glucopyranoside, quercetin 3-O- -(6 -O-galloyl)-glucopyranoside, curcumin, quercetin and kaempferol exhibited significant inhibition.

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